Anti-PTN Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

PTN

Immunogen :

A synthetic peptide of human PTN

Synonym :

HARP;HB-GAM;HBBM;HBGF-8;HBGF8;HBNF;HBNF-1;NEGF1;OSF-1

Isotype :

IgG

Gene ID :

5764

Clone No :

Swiss Port :

P21246

Molecular weight :

19kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB

Recommended dilution :

WB 1:500-2000.

Subcellular location :

Secreted

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTNgene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.