Anti-ANPEP Polyclonal Antibody

No :   K007597P
Size :   
Quantity :   
PRODUCT DESCRIPTION

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ANPEP

Immunogen :

A synthetic peptide of human ANPEP

Synonym :

APN;CD13;LAP1;P150;PEPN;GP150

Isotype :

IgG

Gene ID :

290

Clone No :

Swiss Port :

P15144

Molecular weight :

110kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Cell membrane Cytoplasm Single-pass type II membrane protein cytosol

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS.
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