Anti-ABCB11 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ABCB11

Immunogen :

A synthetic peptide of human ABCB11

Synonym :

BSEP;PGY4;SPGP;ABC16;BRIC2;PFIC2;PFIC-2

Isotype :

IgG

Gene ID :

8647

Clone No :

Swiss Port :

O95342

Molecular weight :

146kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:10-50.

Subcellular location :

Membrane Multi-pass membrane protein

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.