Anti-PRMT5 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

PRMT5

Immunogen :

A synthetic peptide of human PRMT5

Synonym :

JBP1;SKB1;IBP72;SKB1Hs;HRMT1L5

Isotype :

IgG

Gene ID :

10419

Clone No :

Swiss Port :

O14744

Molecular weight :

54/68/71/73kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB

Recommended dilution :

WB 1:500-2000.

Subcellular location :

Cytoplasm Golgi apparatus Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.