PRODUCT DESCRIPTION
Conjugation :
UnconjugateHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
ZAP70Immunogen :
Recombinant protein of human ZAP70Synonym :
ADMIO2;IMD48;SRK;STCD;STD;TZK;ZAP-70;SRK;STCD;STD;TZK;ZAP-70Isotype :
IgGGene ID :
7535Clone No :
Swiss Port :
P43403Molecular weight :
70kDaPurification :
Affinity purificationReactivity :
Human MouseApplication :
WB IHCRecommended dilution :
WB 1:500-2000. IHC 1:10-100.Subcellular location :
Cell membrane Cytoplasm Peripheral membrane proteinStorage :
Store at -20°C. Avoid freeze / thaw cycles.Background :
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.RELATED PRODUCTS
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REFERENCE LIBRARY
No data