Anti-DFFB Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

DFFB

Immunogen :

A synthetic peptide of human DFFB

Synonym :

CAD;CPAN;DFF-40;DFF2;DFF40;DNA fragmentation factor subunit beta

Isotype :

IgG

Gene ID :

1677

Clone No :

Swiss Port :

O76075

Molecular weight :

39kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Cytoplasm Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined.