Anti-NPR1 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

NPR1

Immunogen :

A synthetic peptide of human NPR1

Synonym :

ANPa;NPRA;ANPRA;GUC2A;GUCY2A

Isotype :

IgG

Gene ID :

4881

Clone No :

Swiss Port :

P16066

Molecular weight :

119kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC ELISA

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms . The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).