PRODUCT DESCRIPTION
Conjugation :
UnconjugateHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
APAF1Immunogen :
A synthetic peptide of human APAF1Synonym :
CED4Isotype :
IgGGene ID :
317Clone No :
Swiss Port :
O14727Molecular weight :
142kDaPurification :
Affinity purificationReactivity :
Human Mouse RatApplication :
WBRecommended dilution :
WB 1:200-1000. IHC 1:25-100.Subcellular location :
CytoplasmStorage :
Store at -20°C. Avoid freeze / thaw cycles.Background :
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.RELATED PRODUCTS
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REFERENCE LIBRARY
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