Anti-EIF2S1 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

EIF2S1

Immunogen :

A synthetic peptide of human EIF2S1

Synonym :

EIF2;EIF-2;EIF2A;EIF-2A;EIF-2alpha

Isotype :

IgG

Gene ID :

1965

Clone No :

Swiss Port :

P05198

Molecular weight :

36kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:500-2000. IHC 1:10-100.

Subcellular location :

Cytoplasmic granule

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).