Anti-VGLL1 Polyclonal Antibody

No :   K007353P
Size :   
Quantity :   
PRODUCT DESCRIPTION

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

VGLL1

Immunogen :

A synthetic peptide of human VGLL1

Synonym :

TDU;VGL1

Isotype :

IgG

Gene ID :

51442

Clone No :

Swiss Port :

Q99990

Molecular weight :

29kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB

Recommended dilution :

WB 1:2000-10000.

Subcellular location :

Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.
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REFERENCE LIBRARY
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