PRODUCT DESCRIPTION
Conjugation :
UnconjugateHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
IMPA1Immunogen :
Recombinant protein of human IMPA1Synonym :
IMP;IMPA;MRT59Isotype :
IgGGene ID :
3612Clone No :
Swiss Port :
P29218Molecular weight :
30kDaPurification :
Affinity purificationReactivity :
Human Mouse RatApplication :
WB IHCRecommended dilution :
WB 1:500-2000. IHC 1:25-100.Subcellular location :
Cytoplasm NucleusStorage :
Store at -20°C. Avoid freeze / thaw cycles.Background :
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.RELATED PRODUCTS
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REFERENCE LIBRARY
No data