Anti-FGR Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

FGR

Immunogen :

A synthetic peptide of human FGR

Synonym :

SRC2;c-fgr;c-src2;p55-Fgr;p58-Fgr;p55c-fgr;p58c-fgr

Isotype :

IgG

Gene ID :

2268

Clone No :

Swiss Port :

P09769

Molecular weight :

59kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Cell membrane Cell projection Cytoplasm Cytoplasmic side Lipid-anchor Mitochondrion inner membrane Mitochondrion intermembrane space Peripheral membrane protein cytoskeleton cytosol ruffle membrane

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.