Anti-CCM2 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CCM2

Immunogen :

Recombinant protein of human CCM2

Synonym :

OSM;C7orf22;PP10187

Isotype :

IgG

Gene ID :

83605

Clone No :

Swiss Port :

Q9BSQ5

Molecular weight :

49kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.