Anti-C4BPB Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

C4BPB

Immunogen :

Recombinant protein of human C4BPB

Synonym :

C4BP

Isotype :

IgG

Gene ID :

725

Clone No :

Swiss Port :

P20851

Molecular weight :

28kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Secreted Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.