Anti-CBX2 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CBX2

Immunogen :

Recombinant protein of human CBX2

Synonym :

CDCA6;M33;SRXY5

Isotype :

IgG

Gene ID :

84733

Clone No :

Swiss Port :

Q14781

Molecular weight :

23/56kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:100-300.

Subcellular location :

Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) . Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.