Anti-MSN Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

MSN

Immunogen :

A synthetic peptide of human MSN

Synonym :

Epididymis luminal protein 70;HEL70;Membrane organizing extension spike protein;Membrane-organizing extension spike protein;MOES_HUMAN;Moesin;Moesin/anaplastic lymphoma kinase fusion protein;Msn;MSN/ALK fusion;CB567;CG12537;DFNB24;ESP10;Hh-induced MATH and BTB domain-containing protein;HIB;Moesin-B;Protein roadkill;RADI_HUMAN;Radixin;RDX;Villin 2 ezrin;CVIL;CVL;Cytovillin 2;Cytovillin;DKFZp762H157;Epididymis secretory protein Li 105;EZR;EZRI_HUMAN;Ezrin;FLJ26216;HEL S 105;MGC1584;p81;VIL 2;VIL2;Villin 2 (ezrin);Villin 2;Villin-2;Villin2;

Isotype :

IgG

Gene ID :

4478

Clone No :

Swiss Port :

P26038

Molecular weight :

68kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat Cow Monkey

Application :

WB IHC IF

Recommended dilution :

WB 1:8000-12000. IHC 1:100-300. IF 1:50-200

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation.