PRODUCT DESCRIPTION
Conjugation :
UnconjugationHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
TNK2Immunogen :
Recombinant protein of human TNK2Synonym :
TNK2;ACK;ACK-1;ACK1;p21cdc42HsIsotype :
IgGGene ID :
10188Clone No :
Swiss Port :
Q07912Molecular weight :
60/114/119kDaPurification :
Affinity purificationReactivity :
HumanApplication :
WB IHC IFRecommended dilution :
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.Subcellular location :
Cell junction Cell membrane Cytoplasmic side Cytoplasmic vesicle Cytoplasmic vesicle membrane Endosome Membrane Nucleus Peripheral membrane protein Adherens junction Clathrin-coated pit Cathrin-coated vesicleStorage :
Store at -20°C. Avoid freeze / thaw cycles.Background :
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.RELATED PRODUCTS
No data
REFERENCE LIBRARY
No data