Anti-TNK2 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TNK2

Immunogen :

Recombinant protein of human TNK2

Synonym :

TNK2;ACK;ACK-1;ACK1;p21cdc42Hs

Isotype :

IgG

Gene ID :

10188

Clone No :

Swiss Port :

Q07912

Molecular weight :

60/114/119kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB IHC IF

Recommended dilution :

WB 1:500-2000. IHC 1:50-200. IF 1:50-200.

Subcellular location :

Cell junction Cell membrane Cytoplasmic side Cytoplasmic vesicle Cytoplasmic vesicle membrane Endosome Membrane Nucleus Peripheral membrane protein Adherens junction Clathrin-coated pit Cathrin-coated vesicle

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.