Anti-TLR4 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TLR4

Immunogen :

A synthetic peptide of human TLR4

Synonym :

ARMD10;CD284;hToll;TLR-4

Isotype :

IgG

Gene ID :

7099

Clone No :

Swiss Port :

O00206

Molecular weight :

73/91/96kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB FC

Recommended dilution :

WB 1:500-1000. FC 1:20-50.

Subcellular location :

Cell membrane Single-pass type I membrane protein Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.